Loss of Pex1 in Inner Ear Hair Cells Contributes to Cochlear Synaptopathy and Hearing Loss

Loss of Pex1 in Inner Ear Hair Cells Contributes to Cochlear Synaptopathy and Hearing Loss

Peroxisome Biogenesis Disorders (PBD) and Zellweger syndrome spectrum disorders (ZSD) are rare genetic multisystem disorders that include hearing impairment and are associated with defects in peroxisome assembly, function, or both. Mutations in 13 peroxin (<i>PEX</i>) genes have been fou...

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Bibliographic Details
Main Authors: Stephanie A. Mauriac, Thibault Peineau, Aamir Zuberi, Cathleen Lutz, Gwénaëlle S. G. Géléoc
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
Pex1
hearing loss
peroxisome
synapse
hair cells
PBD-ZSD
Online Access:https://www.mdpi.com/2073-4409/11/24/3982

Internet

https://www.mdpi.com/2073-4409/11/24/3982

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