The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts

The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts

Abstract Cancer-associated fibroblasts (CAFs) play critical roles in cancer progression by regulating tumor cell proliferation, angiogenesis, and metastasis. Recent studies demonstrated that CAFs induce inhibitory immune cell infiltration and chemotherapy resistance in gastric cancer by activating t...

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Bibliographic Details
Main Authors: Junjie Gu, Xuechun Li, Lin Zhao, Ying Yang, Chunling Xue, Yang Gao, Jing Li, Qin Han, Zhao Sun, Chunmei Bai, Robert Chunhua Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03579-x

Internet

https://doi.org/10.1038/s41419-021-03579-x

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