Adipose tissue-derived human mesenchymal stromal cells can better suppress complement lysis, engraft and inhibit acute graft-versus-host disease in mice

Adipose tissue-derived human mesenchymal stromal cells can better suppress complement lysis, engraft and inhibit acute graft-versus-host disease in mice

Abstract Background Acute graft-versus-host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). Transplantation of immunosuppressive human mesenchymal stromal cells (hMSCs) can protect against aGvHD post-HSCT; however, their efficacy is li...

Full description

Bibliographic Details
Main Authors: Stanley Chun Ming Wu, Manyu Zhu, Stanley C. C. Chik, Maxwell Kwok, Asif Javed, Laalaa Law, Shing Chan, Kenneth R. Boheler, Yin Ping Liu, Godfrey Chi Fung Chan, Ellen Ngar-Yun Poon
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Stem Cell Research & Therapy
Subjects:
Human mesenchymal stromal cells
Acute graft-versus-host disease
CD55
Complement
hMSC transplantation
hMSC
Online Access:https://doi.org/10.1186/s13287-023-03380-x

Internet

https://doi.org/10.1186/s13287-023-03380-x

Similar Items