Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing

Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing

Abstract Background Microglia are tissue resident macrophages with a wide range of critically important functions in central nervous system development and homeostasis. Method In this study, we aimed to characterize the transcriptional landscape of ex vivo human microglia across different developmen...

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Bibliographic Details
Main Authors: Moein Yaqubi, Adam M. R. Groh, Marie-France Dorion, Elia Afanasiev, Julia Xiao Xuan Luo, Hadi Hashemi, Sarthak Sinha, Nicholas W. Kieran, Manon Blain, Qiao-Ling Cui, Jeff Biernaskie, Myriam Srour, Roy Dudley, Jeffery A. Hall, Joshua A. Sonnen, Nathalie Arbour, Alexandre Prat, Jo Anne Stratton, Jack Antel, Luke M. Healy
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Neuroinflammation
Subjects:
scRNA-seq
Ex vivo human microglia
Transcriptional heterogeneity
Gene regulatory network
Online Access:https://doi.org/10.1186/s12974-023-02809-7

Internet

https://doi.org/10.1186/s12974-023-02809-7

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