Dopamine‐related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth‐derived stem cells of children with Down syndrome

Dopamine‐related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth‐derived stem cells of children with Down syndrome

Abstract Down syndrome (DS) is one of the common genetic disorders caused by the trisomy of human chromosome 21 (HSA21). Mitochondrial dysfunction and redox imbalance play important roles in DS pathology, and altered dopaminergic regulation has been demonstrated in the brain of individuals with DS....

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Bibliographic Details
Main Authors: Xiao Sun, Hiroki Kato, Hiroshi Sato, Xu Han, Yuta Hirofuji, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:FASEB BioAdvances
Subjects:
dopaminergic neurons
Down syndrome
mitochondria
reactive oxygen species
stem cells from human exfoliated deciduous teeth
Online Access:https://doi.org/10.1096/fba.2021-00086

Internet

https://doi.org/10.1096/fba.2021-00086

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