Molecular and Nano-Structural Optimization of Nanoparticulate Mn<sup>2+</sup>-Hexarhenium Cluster Complexes for Optimal Balance of High T<sub>1</sub>- and T<sub>2</sub>-Weighted Contrast Ability with Low Hemoagglutination and Cytotoxicity

Molecular and Nano-Structural Optimization of Nanoparticulate Mn<sup>2+</sup>-Hexarhenium Cluster Complexes for Optimal Balance of High T<sub>1</sub>- and T<sub>2</sub>-Weighted Contrast Ability with Low Hemoagglutination and Cytotoxicity

The present work introduces rational design of nanoparticulate Mn(II)-based contrast agents through both variation of the μ<sub>3</sub> (inner) ligands within a series of hexarhenium cluster complexes [{Re<sub>6</sub>(μ<sub>3</sub>-Q)<sub>8</sub>}(CN)&...

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Bibliographic Details
Main Authors: Bulat Salavatovich Akhmadeev, Irek R. Nizameev, Kirill V. Kholin, Alexandra D. Voloshina, Tatyana P. Gerasimova, Aidar T. Gubaidullin, Marsil K. Kadirov, Ildus E. Ismaev, Konstantin A. Brylev, Rustem R. Zairov, Asiya R. Mustafina
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
nanoparticles
manganese based contrast agents
MRI
hexarhenium clusters
Online Access:https://www.mdpi.com/1999-4923/14/7/1508

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https://www.mdpi.com/1999-4923/14/7/1508

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