Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo and In Silico Analysis

Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo and In Silico Analysis

Garlic’s main bioactive organosulfur component, diallyl trisulfide (DATS), has been widely investigated in cancer models. However, DATS is not suitable for clinical use due to its low solubility. The current study seeks to improve DATS bioavailability and assess its chemopreventive and chemosensitiz...

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Bibliographic Details
Main Authors: Faris Alrumaihi, Masood Alam Khan, Ali Yousif Babiker, Mohammed Alsaweed, Faizul Azam, Khaled S. Allemailem, Ahmad A. Almatroudi, Syed Rizwan Ahamad, Mahdi H. Alsugoor, Khloud Nawaf Alharbi, Nahlah Makki Almansour, Arif Khan
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
diallyl trisulfide stealth liposomes
doxorubicin PEGylated liposomes
chemoprevention
chemosensitization
colorectal cancer
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/7/2192

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https://www.mdpi.com/1420-3049/27/7/2192

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