The Ras/MAPK pathway is required for generation of iNKT cells.
iNKT cells derive from CD4(+)CD8(+) DP thymocytes, and are selected by thymocyte-thymocyte interactions through signals from their invariant Vα14-Jα18 TCR and from the costimulatory molecules SLAMF1 and SLAMF6. Genetic studies have demonstrated the contribution of different signaling pathways to thi...
| Հիմնական հեղինակներ: | , , , , |
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| Ձևաչափ: | Հոդված |
| Լեզու: | English |
| Հրապարակվել է: |
Public Library of Science (PLoS)
2011-05-01
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| Շարք: | PLoS ONE |
| Առցանց հասանելիություն: | http://europepmc.org/articles/PMC3091886?pdf=render |