Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids

Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids

Glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins is the most complex and metabolically expensive of the lipid posttranslational modifications described to date. The GPI anchor is synthesized via a membrane-bound multistep pathway in the endoplasmic reticulum (ER) requiring >2...

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Bibliographic Details
Main Authors: Orlean Peter, Anant K. Menon
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Journal of Lipid Research
Subjects:
glycosyltransferase
flippase
dolichol
phosphatidylethanolamine
phosphatidylinositol
endoplasmic reticulum
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520435461

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http://www.sciencedirect.com/science/article/pii/S0022227520435461

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