Multi-functionality of a tryptophan residue conserved in substrate-binding groove of GH19 chitinases

Abstract GH19 and GH22 glycoside hydrolases belonging to the lysozyme superfamily have a related structure/function. A highly conserved tryptophan residue, Trp103, located in the binding groove of a GH19 chitinase from moss Bryum coronatum (BcChi-A) appears to have a function similar to that of well...

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Bibliographic Details
Main Authors: Takuya Nagata, Shoko Shinya, Takayuki Ohnuma, Tamo Fukamizo
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81903-3