Single‐Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids

Single‐Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids

Abstract Molecular heterogeneity of hepatobiliary tumor including intertumoral and intratumoral disparity always leads to drug resistance. Here, seven hepatobiliary tumor organoids are generated to explore heterogeneity and evolution via single‐cell RNA sequencing. HCC272 with high status of epithel...

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Bibliographic Details
Main Authors: Yan Zhao, Zhi‐Xuan Li, Yan‐Jing Zhu, Jing Fu, Xiao‐Fang Zhao, Ya‐Ni Zhang, Shan Wang, Jian‐Min Wu, Kai‐Ting Wang, Rui Wu, Cheng‐Jun Sui, Si‐Yun Shen, Xuan Wu, Hong‐Yang Wang, Dong Gao, Lei Chen
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Advanced Science
Subjects:
drug resistance
hepatobiliary tumor organoid
single‐cell analysis
tumor ecosystem
tumor heterogeneity
Online Access:https://doi.org/10.1002/advs.202003897

Internet

https://doi.org/10.1002/advs.202003897

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