The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma
Anoikis is a specialized mode of programmed cell death. Specifically, once cells detach from the original extracellular matrix, an apoptotic program is initiated, preventing colonization of the cells in distant parts of the organ. Therefore, both distant metastasis and colonization of cancer cells r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1009984/full |
| _version_ | 1811257884079554560 |
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| author | Jin Wang Xiaochen Qi Qifei Wang Guangzhen Wu |
| author_facet | Jin Wang Xiaochen Qi Qifei Wang Guangzhen Wu |
| author_sort | Jin Wang |
| collection | DOAJ |
| description | Anoikis is a specialized mode of programmed cell death. Specifically, once cells detach from the original extracellular matrix, an apoptotic program is initiated, preventing colonization of the cells in distant parts of the organ. Therefore, both distant metastasis and colonization of cancer cells rely on the anoikis resistance of cancer cells. Bioinformatics analysis was performed to confirm the relation of anoikis to kidney renal cell carcinoma (KIRC). To construct a prognostic model for patients with KIRC, we investigated several genes of the anoikis pathway most closely related to KIRC and also contrasted the effects of common anticancer drugs on the KIRC pathway. Besides KIRC, we explored the expression of anoikis-related genes in various other cancers. We classified patients with KIRC into three clusters based on the coefficients and mRNA expression levels of anoikis-related genes selected using the GSVA algorithm. We used the GDSC database to predict the response of the anoikis pathway to common anticancer drugs and explored the potential targets of the anoikis pathway in KIRC. We then analyzed the response of common immunotherapies to the anoikis pathway to analyze the correlation between anoikis and immune checkpoint inhibitor therapy. Finally, eleven cancer-related genes were screened and a prognostic model was constructed using LASSO regression. |
| first_indexed | 2024-04-12T18:04:35Z |
| format | Article |
| id | doaj.art-af8d768abdfb436c91ffac2112cad756 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T18:04:35Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-af8d768abdfb436c91ffac2112cad7562022-12-22T03:22:02ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.10099841009984The role and therapeutic significance of the anoikis pathway in renal clear cell carcinomaJin WangXiaochen QiQifei WangGuangzhen WuAnoikis is a specialized mode of programmed cell death. Specifically, once cells detach from the original extracellular matrix, an apoptotic program is initiated, preventing colonization of the cells in distant parts of the organ. Therefore, both distant metastasis and colonization of cancer cells rely on the anoikis resistance of cancer cells. Bioinformatics analysis was performed to confirm the relation of anoikis to kidney renal cell carcinoma (KIRC). To construct a prognostic model for patients with KIRC, we investigated several genes of the anoikis pathway most closely related to KIRC and also contrasted the effects of common anticancer drugs on the KIRC pathway. Besides KIRC, we explored the expression of anoikis-related genes in various other cancers. We classified patients with KIRC into three clusters based on the coefficients and mRNA expression levels of anoikis-related genes selected using the GSVA algorithm. We used the GDSC database to predict the response of the anoikis pathway to common anticancer drugs and explored the potential targets of the anoikis pathway in KIRC. We then analyzed the response of common immunotherapies to the anoikis pathway to analyze the correlation between anoikis and immune checkpoint inhibitor therapy. Finally, eleven cancer-related genes were screened and a prognostic model was constructed using LASSO regression.https://www.frontiersin.org/articles/10.3389/fonc.2022.1009984/fullKIRCanoikisbioinformatics analysiscell deathtarget therapy |
| spellingShingle | Jin Wang Xiaochen Qi Qifei Wang Guangzhen Wu The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma Frontiers in Oncology KIRC anoikis bioinformatics analysis cell death target therapy |
| title | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
| title_full | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
| title_fullStr | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
| title_full_unstemmed | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
| title_short | The role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
| title_sort | role and therapeutic significance of the anoikis pathway in renal clear cell carcinoma |
| topic | KIRC anoikis bioinformatics analysis cell death target therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1009984/full |
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