Bergapten ameliorates combined allergic rhinitis and asthma syndrome after PM2.5 exposure by balancing Treg/Th17 expression and suppressing STAT3 and MAPK activation in a mouse model

Bergapten ameliorates combined allergic rhinitis and asthma syndrome after PM2.5 exposure by balancing Treg/Th17 expression and suppressing STAT3 and MAPK activation in a mouse model

Combined allergic rhinitis and asthma syndrome (CARAS) causes chronic respiratory inflammation in allergic individuals. Long-term exposure to particulate matter 2.5 (PM2.5; particles 2.5 µm or less in diameter) can aggravate respiratory damage. Bergapten (5-methoxysporalen) is a furocoumarin mostly...

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Bibliographic Details
Main Authors: Yuna Jiang, Thi Van Nguyen, Juan Jin, Zhen Nan Yu, Chang Ho Song, Ok Hee Chai
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
CARAS
PM2.5
Bergapten
Treg/Th17 balance
STAT3
MAPK pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223007497

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http://www.sciencedirect.com/science/article/pii/S0753332223007497

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