Supraspinal and Peripheral, but Not Intrathecal, σ1R Blockade by S1RA Enhances Morphine Antinociception

Supraspinal and Peripheral, but Not Intrathecal, σ1R Blockade by S1RA Enhances Morphine Antinociception

Sigma-1 receptor (σ1R) antagonism increases the effects of morphine on acute nociceptive pain. S1RA (E-52862) is a selective σ1R antagonist widely used to study the role of σ1Rs. S1RA alone exerted antinociceptive effect in the formalin test in rats and increased noradrenaline levels in the spinal c...

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Bibliographic Details
Main Authors: Alba Vidal-Torres, Begoña Fernández-Pastor, Alicia Carceller, José Miguel Vela, Manuel Merlos, Daniel Zamanillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
sigma-1 receptor
S1RA
morphine
nociceptive pain
antinociceptive effect
concentric microdialysis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00422/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00422/full

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