REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats

REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats

Abstract REL-1017 (esmethadone, d-methadone) is the opioid-inactive d-isomer of racemic d,l-methadone. REL-1017 may exert antidepressant effects via uncompetitive N-methyl-d-aspartate receptor (NMDAR) channel block. As REL-1017 is expected to exert central nervous system activity, full characterizat...

Full description

Bibliographic Details
Main Authors: Jack Henningfield, David Gauvin, Francesco Bifari, Reginald Fant, Megan Shram, August Buchhalter, Judy Ashworth, Ryan Lanier, Marco Pappagallo, Charles Inturrisi, Franco Folli, Sergio Traversa, Paolo L. Manfredi
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15055-3

Internet

https://doi.org/10.1038/s41598-022-15055-3

Similar Items