Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease

Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by neuronal loss and motor dysfunction. Although there is no effective treatment, stem cell transplantation offers a promising therapeutic strategy, but the safety and efficacy of this approach needs to be optimized...

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Bibliographic Details
Main Authors: Abeer Al-Gharaibeh, Rebecca Culver, Andrew N. Stewart, Bhairavi Srinageshwar, Kristin Spelde, Laura Frollo, Nivya Kolli, Darren Story, Leela Paladugu, Sarah Anwar, Andrew Crane, Robert Wyse, Panchanan Maiti, Gary L. Dunbar, Julien Rossignol
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Neuroscience
Subjects:
neural stem cells
Huntington's disease
cell transplantations
YAC128
iPSCs
iPS-NSCs
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00628/full

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http://journal.frontiersin.org/article/10.3389/fnins.2017.00628/full

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