DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma

DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma

Abstract The two p53 homologues p63 and p73 regulate transcriptional programs in epithelial tissues and several cell types in these tissues express both proteins. All members of the p53 family form tetramers in their active state through a dedicated oligomerization domain that structurally assembles...

Full description

Bibliographic Details
Main Authors: Alexander Strubel, Philipp Münick, Oliver Hartmann, Apirat Chaikuad, Birgit Dreier, Jonas V. Schaefer, Jakob Gebel, Christian Osterburg, Marcel Tuppi, Birgit Schäfer, Viktoria Buck, Mathias Rosenfeldt, Stefan Knapp, Andreas Plückthun, Markus E. Diefenbacher, Volker Dötsch
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06213-0

Internet

https://doi.org/10.1038/s41419-023-06213-0

Similar Items