Physiologically‐based pharmacokinetic model to predict doxorubicin and paclitaxel exposure in infants through breast milk

Abstract Limited information is available concerning infant exposure and safety when breastfed by mothers receiving chemotherapy. Whereas defining distribution to breast milk is important to infer drug exposure, infant pharmacokinetics also determine to what extent the infant will be exposed to pote...

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Bibliographic Details
Main Authors: David Damoiseaux, Frédéric Amant, Jos H. Beijnen, Shelby Barnett, Gareth J. Veal, Alwin D. R. Huitema, Thomas P. C. Dorlo
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.13043