Osteoclast-derived small extracellular vesicles induce osteogenic differentiation via inhibiting ARHGAP1

Activated osteoclasts release large amounts of small extracellular vesicles (sEVs) during bone remodeling. However, little is known about whether osteoclast-derived sEVs affect surrounding cells. In this study, osteoclasts were generated by stimulating bone marrow macrophages (BMMs) with macrophage...

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Bibliographic Details
Main Authors: Mengmeng Liang, Xiaofan Yin, Shuai Zhang, Hongbo Ai, Fei Luo, Jianzhong Xu, Ce Dou, Shiwu Dong, Qinyu Ma
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000317