Experimental and Computational Structural Studies of 2,3,5-Trisubstituted and 1,2,3,5-Tetrasubstituted Indoles as Non-Competitive Antagonists of GluK1/GluK2 Receptors

Experimental and Computational Structural Studies of 2,3,5-Trisubstituted and 1,2,3,5-Tetrasubstituted Indoles as Non-Competitive Antagonists of GluK1/GluK2 Receptors

The blockade of kainate receptors, in particular with non-competitive antagonists, has—due to their anticonvulsant and neuroprotective properties—therapeutic potential in many central nervous system (CNS) diseases. Deciphering the structural properties of kainate receptor ligands is crucial to desig...

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Bibliographic Details
Main Authors: Agata Bartyzel, Agnieszka A. Kaczor, Ghodrat Mahmoudi, Ardavan Masoudiasl, Tomasz M. Wróbel, Monika Pitucha, Dariusz Matosiuk
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
indole derivatives
kainate receptor ligands
quantum chemical calculations
X-ray studies
Online Access:https://www.mdpi.com/1420-3049/27/8/2479

Internet

https://www.mdpi.com/1420-3049/27/8/2479

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