Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity

Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity

Our previous studies identified that retinal endothelial damage caused by hyperglycemia or nucleoside diphosphate kinase-B (NDPK-B) deficiency is linked to elevation of angiopoietin-2 (Ang-2) and the activation of the hexosamine biosynthesis pathway (HBP). Herein, we investigated how NDPK-B is invol...

Full description

Bibliographic Details
Main Authors: Anupriya Chatterjee, Rachana Eshwaran, Gernot Poschet, Santosh Lomada, Mahmoud Halawa, Kerstin Wilhelm, Martina Schmidt, Hans-Peter Hammes, Thomas Wieland, Yuxi Feng
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
nucleoside diphosphate kinase B
Ang-2
O-GlcNAcylation
UDP-GlcNAc
OGA
Online Access:https://www.mdpi.com/2073-4409/9/10/2324

Internet

https://www.mdpi.com/2073-4409/9/10/2324

Similar Items