Molecular Mechanisms Linking Empagliflozin to Renal Protection in the LLC-PK1 Model of Diabetic Nephropathy

Molecular Mechanisms Linking Empagliflozin to Renal Protection in the LLC-PK1 Model of Diabetic Nephropathy

Aims: Chronic diabetes complications, including diabetic nephropathy (DN), frequently result in end-stage renal failure. This study investigated empagliflozin (SGLT2i) effects on collagen synthesis, oxidative stress, cell survival, and protein expression in an LLC-PK1 model of DN. Methods: Combinati...

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Bibliographic Details
Main Authors: Vjera Mihaljević, Milorad Zjalić, Tomislav Kizivat, Tea Omanović Kolarić, Martina Smolić, Edi Rođak, Marina Čović, Lucija Kuna, Robert Smolić, Aleksandar Včev, Ines Bilić Ćurčić
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
diabetic nephropathy
TGF-β1
empagliflozin
LLC-PK1 cells
Online Access:https://www.mdpi.com/2227-9059/10/11/2983

Internet

https://www.mdpi.com/2227-9059/10/11/2983

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