A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging

A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging

Abstract Ageing is driven by the progressive, lifelong accumulation of cellular damage. Autophagy (cellular self-eating) functions as a major cell clearance mechanism to degrade such damages, and its capacity declines with age. Despite its physiological and medical significance, it remains largely u...

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Bibliographic Details
Main Authors: Tibor Kovács, Janka Szinyákovics, Viktor Billes, Gábor Murányi, Virginia B. Varga, Annamária Bjelik, Ádám Légrádi, Melinda Szabó, Sára Sándor, Enikő Kubinyi, Cecília Szekeres-Paracky, Péter Szocsics, János Lőke, Jun Mulder, Balázs Gulyás, Éva Renner, Miklós Palkovits, Károly Gulya, Zsófia Maglóczky, Tibor Vellai
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24843-w

Internet

https://doi.org/10.1038/s41598-022-24843-w

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