Coupling the Cardiac Voltage-Gated Sodium Channel to Channelrhodopsin-2 Generates Novel Optical Switches for Action Potential Studies

Coupling the Cardiac Voltage-Gated Sodium Channel to Channelrhodopsin-2 Generates Novel Optical Switches for Action Potential Studies

Voltage-gated sodium (Na<sup>+</sup>) channels respond to short membrane depolarization with conformational changes leading to pore opening, Na<sup>+</sup> influx, and action potential (AP) upstroke. In the present study, we coupled channelrhodopsin-2 (ChR2), the key ion chan...

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Bibliographic Details
Main Authors: Christian vom Dahl, Christoph Emanuel Müller, Xhevat Berisha, Georg Nagel, Thomas Zimmer
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Membranes
Subjects:
optogenetics
channelrhodopsin
voltage-gated Na<sup>+</sup> channel
action potential
delayed rectifier potassium channel
hERG
Online Access:https://www.mdpi.com/2077-0375/12/10/907

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https://www.mdpi.com/2077-0375/12/10/907

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