NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1

NLRP6 deficiency inhibits neuroinflammation and ameliorates brain injury in ischemic stroke by blocking NLRs inflammasomes activation through proteasomal degradation of pro-caspase-1

Innate inflammation is crucial for ischemic stroke development. NLRP6, a nucleotide-binding and oligomerization domain-like receptors (NLRs) family member, regulates innate inflammation. Whether NLRP6 regulates neurological damage and neuroinflammation during ischemic stroke remains unclear. We repo...

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Bibliographic Details
Main Authors: Qi He, Changchang Meng, Mengjie Jia, Junyi Tan, Keli Huang, Hui Gan, Lingyu Li, Jing Zhao
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Neurobiology of Disease
Subjects:
Ischemic stroke
Innate inflammation
Inflammasome
NLRP6
Pro-caspase-1
NLRP3
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124000330

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http://www.sciencedirect.com/science/article/pii/S0969996124000330

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