On the feasibility of using TCR sequencing to follow a vaccination response – lessons learned

On the feasibility of using TCR sequencing to follow a vaccination response – lessons learned

T cells recognize pathogens by their highly specific T-cell receptor (TCR), which can bind small fragments of an antigen presented on the Major Histocompatibility Complex (MHC). Antigens that are provided through vaccination cause specific T cells to respond by expanding and forming specific memory...

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Bibliographic Details
Main Authors: Peter C. de Greef, Josien Lanfermeijer, Marion Hendriks, Alper Cevirgel, Martijn Vos, José A. M. Borghans, Debbie van Baarle, Rob J. de Boer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
TCR - T cell receptor
pneumococcal 13-valent polysaccharide vaccine
immune response
high-throughput sequencing
vaccination
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1210168/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1210168/full

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