T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens

T lymphocytes’ ability to discriminate between structurally related antigens has been attributed to the unique signaling properties of the T cell receptor. However, recent studies have suggested that the output of this discrimination process is conditioned by environmental cues. Here, we demonstrate...

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Detalles Bibliográficos
Autores principales: Guillaume Voisinne, Briana G. Nixon, Anna Melbinger, Georg Gasteiger, Massimo Vergassola, Grégoire Altan-Bonnet
Formato: Artículo
Lenguaje:English
Publicado: Elsevier 2015-05-01
Colección:Cell Reports
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2211124715004684