T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens

T lymphocytes’ ability to discriminate between structurally related antigens has been attributed to the unique signaling properties of the T cell receptor. However, recent studies have suggested that the output of this discrimination process is conditioned by environmental cues. Here, we demonstrate...

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Bibliographic Details
Main Authors: Guillaume Voisinne, Briana G. Nixon, Anna Melbinger, Georg Gasteiger, Massimo Vergassola, Grégoire Altan-Bonnet
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715004684