Superenhancers as master gene regulators and novel therapeutic targets in brain tumors
Brain cancer: opportunities to block “super-enhanced” tumor growth “Superenhancer” regions within the genome help coordinate the malignant growth of brain tumors, and could offer a target for the development of therapies and prognostic biomarkers. These regions contain a dense accumulation of gene r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-02-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-00934-0 |
| _version_ | 1797865490914213888 |
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| author | Hai-Hui Zhuang Qiang Qu Xin-Qi Teng Ying-Huan Dai Jian Qu |
| author_facet | Hai-Hui Zhuang Qiang Qu Xin-Qi Teng Ying-Huan Dai Jian Qu |
| author_sort | Hai-Hui Zhuang |
| collection | DOAJ |
| description | Brain cancer: opportunities to block “super-enhanced” tumor growth “Superenhancer” regions within the genome help coordinate the malignant growth of brain tumors, and could offer a target for the development of therapies and prognostic biomarkers. These regions contain a dense accumulation of gene regulatory sequences, which operate in collaboration to establish cellular identity. A review by Jian Qu and colleagues at Central South University, Changsha, China, shows how these regulatory sequences get hijacked in various brain cancers and can facilitate tumor cell proliferation and invasion. Many tumor cells acquire mutations that lead to the formation of superenhancers that are absent in healthy cells. However, this process also offers therapeutic opportunities, and researchers have identified numerous drug candidates that can potentially block tumorigenesis by selectively interfering with superenhancer function. Superenhancer activity could also provide a potentially useful clinical signature for assessing tumor aggressiveness. |
| first_indexed | 2024-04-09T23:09:11Z |
| format | Article |
| id | doaj.art-afbb23af39304956ad49d92908a8474f |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-04-09T23:09:11Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-afbb23af39304956ad49d92908a8474f2023-03-22T10:31:22ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-02-0155229030310.1038/s12276-023-00934-0Superenhancers as master gene regulators and novel therapeutic targets in brain tumorsHai-Hui Zhuang0Qiang Qu1Xin-Qi Teng2Ying-Huan Dai3Jian Qu4Department of Pharmacy, the Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South UniversityDepartment of Pharmacy, Xiangya Hospital, Central South UniversityDepartment of Pharmacy, the Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South UniversityDepartment of Pathology, the Second Xiangya Hospital, Central South UniversityDepartment of Pharmacy, the Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South UniversityBrain cancer: opportunities to block “super-enhanced” tumor growth “Superenhancer” regions within the genome help coordinate the malignant growth of brain tumors, and could offer a target for the development of therapies and prognostic biomarkers. These regions contain a dense accumulation of gene regulatory sequences, which operate in collaboration to establish cellular identity. A review by Jian Qu and colleagues at Central South University, Changsha, China, shows how these regulatory sequences get hijacked in various brain cancers and can facilitate tumor cell proliferation and invasion. Many tumor cells acquire mutations that lead to the formation of superenhancers that are absent in healthy cells. However, this process also offers therapeutic opportunities, and researchers have identified numerous drug candidates that can potentially block tumorigenesis by selectively interfering with superenhancer function. Superenhancer activity could also provide a potentially useful clinical signature for assessing tumor aggressiveness.https://doi.org/10.1038/s12276-023-00934-0 |
| spellingShingle | Hai-Hui Zhuang Qiang Qu Xin-Qi Teng Ying-Huan Dai Jian Qu Superenhancers as master gene regulators and novel therapeutic targets in brain tumors Experimental and Molecular Medicine |
| title | Superenhancers as master gene regulators and novel therapeutic targets in brain tumors |
| title_full | Superenhancers as master gene regulators and novel therapeutic targets in brain tumors |
| title_fullStr | Superenhancers as master gene regulators and novel therapeutic targets in brain tumors |
| title_full_unstemmed | Superenhancers as master gene regulators and novel therapeutic targets in brain tumors |
| title_short | Superenhancers as master gene regulators and novel therapeutic targets in brain tumors |
| title_sort | superenhancers as master gene regulators and novel therapeutic targets in brain tumors |
| url | https://doi.org/10.1038/s12276-023-00934-0 |
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