Comprehensive Genomic Profiling-Guided Niraparib Treatment of Triple-Negative Breast Cancer in a Patient With Extensive Brain Metastasis: Case Report and Literature Review

Comprehensive Genomic Profiling-Guided Niraparib Treatment of Triple-Negative Breast Cancer in a Patient With Extensive Brain Metastasis: Case Report and Literature Review

Homologous recombination deficiency (HRD) is a common phenotypic alteration that is highly druggable with poly (ADP-ribose) polymerase inhibitors (PARPi). Although BRCA1/2 gene mutations are among the commonest genomic aberrations associated with HRD, defects in other DNA damage repair (DDR) genes a...

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Bibliographic Details
Main Author: Tai-Chung Lam
Format: Article
Language:English
Published: Innovative Healthcare Institute 2021-02-01
Series:Journal of Immunotherapy and Precision Oncology
Subjects:
comprehensive genomic profiling
niraparib
triple-negative breast cancer
brain metastasis
precision oncology
Online Access:https://jipo.org/doi/pdf/10.36401/JIPO-20-24

Internet

https://jipo.org/doi/pdf/10.36401/JIPO-20-24

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