Comprehensive Genomic Profiling-Guided Niraparib Treatment of Triple-Negative Breast Cancer in a Patient With Extensive Brain Metastasis: Case Report and Literature Review
Homologous recombination deficiency (HRD) is a common phenotypic alteration that is highly druggable with poly (ADP-ribose) polymerase inhibitors (PARPi). Although BRCA1/2 gene mutations are among the commonest genomic aberrations associated with HRD, defects in other DNA damage repair (DDR) genes a...
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| Format: | Article |
| Language: | English |
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Innovative Healthcare Institute
2021-02-01
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| Series: | Journal of Immunotherapy and Precision Oncology |
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| Online Access: | https://jipo.org/doi/pdf/10.36401/JIPO-20-24 |