The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

Summary: Circadian clock controls daily behavior and physiology. The activity of various signaling pathways affects clock gene expression. Here, we show that the core circadian clock gene CRY1 is a direct target of the Hippo pathway effector YAP. YAP binds to TEADs and occupies the proximal promoter...

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Bibliographic Details
Main Authors: Abdelhalim Azzi, Zhipeng Tao, Yang Sun, Hannah Erb, Carla Guarino, Xu Wu
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223015262