The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors

The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors

The classical terms agonists and antagonists for G protein coupled receptors (GPCRs) have often become misleading. Even the biased agonism concept does not describe all the possibilities already demonstrated for GPCRs. The cannabinoid CB2 receptor (CB2R) emerged as a promising target for a variety o...

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Bibliographic Details
Main Authors: Rafael Franco, Paula Morales, Gemma Navarro, Nadine Jagerovic, Irene Reyes-Resina
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
biased agonism
heteromer
health benefits
therapy
functional selectivity
cannabinoid receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.852631/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.852631/full

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