Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression

Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression

Shank is a post-synaptic scaffolding protein that has many binding partners. Shank mutations and copy number variations (CNVs) are linked to several psychiatric disorders, and to synaptic and behavioral defects in mice. It is not known which Shank binding partners are responsible for these defects....

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Bibliographic Details
Main Authors: Edward Pym, Nikhil Sasidharan, Katherine L Thompson-Peer, David J Simon, Anthony Anselmo, Ruslan Sadreyev, Qi Hall, Stephen Nurrish, Joshua M Kaplan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
C. elegans
Shank
SHN-1
L-type channel
CREB
autism
Online Access:https://elifesciences.org/articles/18931

Internet

https://elifesciences.org/articles/18931

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