A New Framework to Implement Model-Informed Dosing in Clinical Guidelines: Piperacillin and Amikacin as Proof of Concept

A New Framework to Implement Model-Informed Dosing in Clinical Guidelines: Piperacillin and Amikacin as Proof of Concept

Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guideline...

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Bibliographic Details
Main Authors: Stan J. F. Hartman, Joost G. E. Swaving, Stijn W. van Beek, Bianca D. van Groen, Marika de Hoop, Tjitske M. van der Zanden, Rob ter Heine, Saskia N. de Wildt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
pharmacokinetics
model-informed dosing
clinical implementation
critically ill children
piperacillin
amikacin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.592204/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.592204/full

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