G protein coupling and activation of the metabotropic GABAB heterodimer
Despite its crucial role in the central nervous system, little is known about the activation mechanism of GABAB receptor. Here, the authors predict that the inactive G protein induces conformational changes of the receptor to form an intermediate state.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32213-3 |