Hemopexin alleviates cognitive dysfunction after focal cerebral ischemia-reperfusion injury in rats

Abstract Background Ischemia-reperfusion (I/R) is a critical pathophysiological basis of cognitive dysfunction caused by ischemia stroke. Heme-oxygenase-1 (HO-1) is the rate-limiting enzyme for the elimination of excessive free heme by combining with hemopexin (HPX), a plasma protein that contribute...

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Bibliographic Details
Main Authors: Beibei Dong, Yongyan Yang, Zhishen Zhang, Keliang Xie, Lin Su, Yonghao Yu
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Anesthesiology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12871-019-0681-2