Cartilage type IIB procollagen NH2-propeptide, PIIBNP, inhibits angiogenesis
Cartilage tissue is avascular and resistant to tumor invasion, but the basis for these properties is still unclear. Here we report that the NH2-propeptide of type IIB procollagen (PIIBNP), a product of collagen biosynthesis, is capable of inhibiting angiogenesis both in vitro and in vivo. PIIBNP inh...
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| Format: | Article |
| Language: | English |
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AIMS Press
2021-12-01
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| Series: | AIMS Molecular Science |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/molsci.2021022?viewType=HTML |
| _version_ | 1828522783833849856 |
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| author | Zhepeng Wang Aiwu Lu |
| author_facet | Zhepeng Wang Aiwu Lu |
| author_sort | Zhepeng Wang |
| collection | DOAJ |
| description | Cartilage tissue is avascular and resistant to tumor invasion, but the basis for these properties is still unclear. Here we report that the NH2-propeptide of type IIB procollagen (PIIBNP), a product of collagen biosynthesis, is capable of inhibiting angiogenesis both in vitro and in vivo. PIIBNP inhibits tube formation in human umbilical vein cells (HUVEC), inhibits endogenous endothelial cell outgrowth in mouse aortic ring angiogenesis bioassay and is anti-angiogenic in the mouse cornea angiogenesis assay. As αVß3 and αVß5 integrins are expressed primarily in endothelial cells, cancer cells and osteoclasts, but not in normal chondrocytes and PIIBNP binds to cell surface integrin αVß3 and αVß5, we propose that natural occurring PIIBNP protects cartilage by targeting endothelial cells during chondrogenesis, thus inhibiting angiogenesis, and rendering the tissue avascular. |
| first_indexed | 2024-12-11T20:15:30Z |
| format | Article |
| id | doaj.art-afce36e283d5421f90632817d72e1171 |
| institution | Directory Open Access Journal |
| issn | 2372-0301 |
| language | English |
| last_indexed | 2024-12-11T20:15:30Z |
| publishDate | 2021-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj.art-afce36e283d5421f90632817d72e11712022-12-22T00:52:12ZengAIMS PressAIMS Molecular Science2372-03012021-12-018429130010.3934/molsci.2021022Cartilage type IIB procollagen NH2-propeptide, PIIBNP, inhibits angiogenesisZhepeng Wang 0Aiwu Lu11. Department of Anesthesiology, University of Massachusetts Chan Medical School, 55 N. Lake Avenue, Worcester, MA 01655, USA2. Department of Orthopaedic Surgery, Washington University School of Medicine, USACartilage tissue is avascular and resistant to tumor invasion, but the basis for these properties is still unclear. Here we report that the NH2-propeptide of type IIB procollagen (PIIBNP), a product of collagen biosynthesis, is capable of inhibiting angiogenesis both in vitro and in vivo. PIIBNP inhibits tube formation in human umbilical vein cells (HUVEC), inhibits endogenous endothelial cell outgrowth in mouse aortic ring angiogenesis bioassay and is anti-angiogenic in the mouse cornea angiogenesis assay. As αVß3 and αVß5 integrins are expressed primarily in endothelial cells, cancer cells and osteoclasts, but not in normal chondrocytes and PIIBNP binds to cell surface integrin αVß3 and αVß5, we propose that natural occurring PIIBNP protects cartilage by targeting endothelial cells during chondrogenesis, thus inhibiting angiogenesis, and rendering the tissue avascular.https://www.aimspress.com/article/doi/10.3934/molsci.2021022?viewType=HTMLcartilagenh2-propeptideavascularityangiogenesisinhibitor |
| spellingShingle | Zhepeng Wang Aiwu Lu Cartilage type IIB procollagen NH2-propeptide, PIIBNP, inhibits angiogenesis AIMS Molecular Science cartilage nh2-propeptide avascularity angiogenesis inhibitor |
| title | Cartilage type IIB procollagen NH2-propeptide, PIIBNP, inhibits angiogenesis |
| title_full | Cartilage type IIB procollagen NH2-propeptide, PIIBNP, inhibits angiogenesis |
| title_fullStr | Cartilage type IIB procollagen NH2-propeptide, PIIBNP, inhibits angiogenesis |
| title_full_unstemmed | Cartilage type IIB procollagen NH2-propeptide, PIIBNP, inhibits angiogenesis |
| title_short | Cartilage type IIB procollagen NH2-propeptide, PIIBNP, inhibits angiogenesis |
| title_sort | cartilage type iib procollagen nh2 propeptide piibnp inhibits angiogenesis |
| topic | cartilage nh2-propeptide avascularity angiogenesis inhibitor |
| url | https://www.aimspress.com/article/doi/10.3934/molsci.2021022?viewType=HTML |
| work_keys_str_mv | AT zhepengwang cartilagetypeiibprocollagennh2propeptidepiibnpinhibitsangiogenesis AT aiwulu cartilagetypeiibprocollagennh2propeptidepiibnpinhibitsangiogenesis |