Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human host cells via LINE-1 retrotransposon

Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human host cells via LINE-1 retrotransposon

The horizontal transfer of Trypanosoma cruzi mitochondrial minicircle DNA to the genomes of naturally infected humans may play an important role in the pathogenesis of Chagas disease. Minicircle integrations within LINE-1 elements create the potential for foreign DNA mobility within the host genome...

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Bibliographic Details
Main Authors: Augusto Simões-Barbosa, Enrique R Argañaraz, Ana Maria Barros, Ana de Cássia Rosa, Nivaldo P Alves, Patrícia Louvandini, Marian R D'Souza-Ault, Nadjar Nitz, Nancy R Sturm, Rubens J Nascimento, Antonio RL Teixeira
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2006-12-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
kinetoplast
horizontal transfer
p15
mutagenesis
pathogenesis
retrotransposition
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800003

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800003

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