Sialic acid blockade inhibits the metastatic spread of prostate cancer to boneResearch in context

Sialic acid blockade inhibits the metastatic spread of prostate cancer to boneResearch in context

Summary: Background: Bone metastasis is a common consequence of advanced prostate cancer. Bisphosphonates can be used to manage symptoms, but there are currently no curative treatments available. Altered tumour cell glycosylation is a hallmark of cancer and is an important driver of a malignant phe...

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Main Authors: Kirsty Hodgson, Margarita Orozco-Moreno, Emily Archer Goode, Matthew Fisher, Rebecca Garnham, Richard Beatson, Helen Turner, Karen Livermore, Yuhan Zhou, Laura Wilson, Eline A. Visser, Johan FA. Pijnenborg, Nienke Eerden, Sam J. Moons, Emiel Rossing, Gerald Hysenaj, Rashi Krishna, Ziqian Peng, Kyla Putri Nangkana, Edward N. Schmidt, Adam Duxfield, Ella P. Dennis, Rakesh Heer, Michelle A. Lawson, Matthew Macauley, David J. Elliott, Christian Büll, Emma Scott, Thomas J. Boltje, Richard R. Drake, Ning Wang, Jennifer Munkley
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:EBioMedicine
Subjects:
Prostate cancer
Bone metastasis
Glycans
Sialylation
Sialic acid
Therapeutics
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424001981

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http://www.sciencedirect.com/science/article/pii/S2352396424001981

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