AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function

AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function

Transient Receptor Potential Canonical 6 (TRPC6) has been suggested to be involved in synapse function and contribute to hippocampal-dependent cognitive processes. Gene silencing of TRPC6 was performed by injecting adeno-associated virus (AAV) expressing TRPC6-specific shRNA (shRNA-TRPC6) into the h...

Full description

Bibliographic Details
Main Authors: Ruxin Xie, Zhongke Wang, Tianyao Liu, Rui Xiao, Keyi Lv, Chuan Wu, Yi Luo, Yun Cai, Xiaotang Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TRPC6
hippocampus
cognitive process
synapse
shRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.688655/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.688655/full

Similar Items