Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota

Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota

Unhealthy diet especially high-fat diet (HFD) is the major cause of hyperlipidemia leading to deterioration of chronic kidney diseases (CKD) in patients. Trimethylamine N-oxide (TMAO) is a gut-derived uremic toxin. Our previous clinical study demonstrated that the elevation of TMAO was positively co...

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Bibliographic Details
Main Authors: Zuoyuan Wang, Li You, Yuan Ren, Xiaoye Zhu, Xiaoyi Mao, Xiaowan Liang, Tingting Wang, Yumeng Guo, Te Liu, Jun Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Physiology
Subjects:
trimethylamine N-oxide
gut microbiota
chronic kidney disease
Inflammtory
Finasteride
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.900961/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.900961/full

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