cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging

cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging

Aging is associated with an increased incidence of autoimmune diseases, despite the progressive decline of immune responses (immunosenescence). This apparent paradox can be explained by the age-related chronic low-grade systemic inflammation (inflammaging) and progressive dysregulation of innate sig...

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Bibliographic Details
Main Authors: Carine Raquel Richter Schmitz, Rafael Moura Maurmann, Fatima T. C. R. Guma, Moisés Evandro Bauer, Florencia Maria Barbé-Tuana
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
aging
cGAS
immunosenescence
inflammaging
NF-κB
SASP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1132653/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1132653/full

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