Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1

Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1

Abstract In this largest to-date genetic analysis of anti-drug antibody (ADA) response to a therapeutic monoclonal antibody (MAb), genome-wide association was performed for five measures of ADA status among 8844 individuals randomized to bococizumab, which targets PCSK9 for LDL-C lowering and cardio...

Full description

Bibliographic Details
Main Authors: Daniel I. Chasman, Craig L. Hyde, Franco Giulianini, Rebecca D. Danning, Ellen Q. Wang, Timothy Hickling, Paul M Ridker, A. Katrina Loomis
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-07997-5

Internet

https://doi.org/10.1038/s41598-022-07997-5

Similar Items