Double-dose osimertinib combined with intrathecal injection of pemetrexed improves the efficacy of EGFR-mutant non-small cell lung cancer and leptomeningeal metastasis: case report and literature review

Double-dose osimertinib combined with intrathecal injection of pemetrexed improves the efficacy of EGFR-mutant non-small cell lung cancer and leptomeningeal metastasis: case report and literature review

Leptomeningeal metastasis (LM) is a complication of non-small cell lung cancer (NSCLC) characterized by poor prognosis and short survival. A variety of therapeutic approaches have been sought to improve the efficacy of LM. Here we present a clinical case and conduct a literature review to investigat...

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Bibliographic Details
Main Authors: Wenjuan Zhong, Longqiu Wu, Lixing Huang, Jianfeng Wang, Huaqiu Shi, Shugui Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
leptomeningeal metastasis
osimertinib
pemetrexed
intrathecal chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1377451/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2024.1377451/full

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