Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species

Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species

In a physiological setting, mitochondria increase oxidative phosphorylation during periods of stress to meet increased metabolic demand. This in part is mediated via enhanced mitochondrial Ca2+ uptake, an important regulator of cellular ATP homeostasis. In a pathophysiological setting pharmacologica...

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Bibliographic Details
Main Authors: Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T. Clements, Jin O-Uchi, György Csordás, Bum-Rak Choi, Dmitry Terentyev
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Physiology
Subjects:
mitochondria
reactive oxygen species
ryanodine receptor
hypertrophy
ventricular arrhythmia
Ca2+-induced Ca2+ release
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01831/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01831/full

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