An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets

An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets

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Failures in mitophagy, a process by which damaged mitochondria are cleared, results in neurodegeneration, while enhancing mitophagy promotes the survival of dopaminergic neurons. Using an artificial intelligence platform, we employed a natural language processing approach to evaluate the semantic si...

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Bibliographic Details
Main Authors: Natalia Moskal, Naomi P. Visanji, Olena Gorbenko, Vijay Narasimhan, Hannah Tyrrell, Jess Nash, Peter N. Lewis, G. Angus McQuibban
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-03-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980794/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9980794/?tool=EBI

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