The effect of single-cell knockout of Fragile X Messenger Ribonucleoprotein on synaptic structural plasticity

The effect of single-cell knockout of Fragile X Messenger Ribonucleoprotein on synaptic structural plasticity

Fragile X Syndrome (FXS) is the best-known form of inherited intellectual disability caused by the loss-of-function mutation in a single gene. The FMR1 gene mutation abolishes the expression of Fragile X Messenger Ribonucleoprotein (FMRP), which regulates the expression of many synaptic proteins. Co...

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Bibliographic Details
Main Authors: Marie Gredell, Ju Lu, Yi Zuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Fragile X syndrome (FXS)
FMRP
Fmr1
dendritic spine
synaptic plasticity
cell-autonomous
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2023.1135479/full

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https://www.frontiersin.org/articles/10.3389/fnsyn.2023.1135479/full

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