Mycobacterium tuberculosis Rv1324 Protein Contributes to Mycobacterial Persistence and Causes Pathological Lung Injury in Mice by Inducing Ferroptosis

Mycobacterium tuberculosis Rv1324 Protein Contributes to Mycobacterial Persistence and Causes Pathological Lung Injury in Mice by Inducing Ferroptosis

ABSTRACT Mycobacterium tuberculosis (Mtb) is the pathogenic agent of tuberculosis (TB). Intracellular survival plays a central role in the pathogenesis of Mtb, a process that depends on an array of virulence factors for Mtb to colonize and proliferate within a host. Reactive nitrogen and oxygen spec...

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Bibliographic Details
Main Authors: Xiaoxia Shi, Chunyu Li, Lin Cheng, Hayan Ullah, Shanshan Sha, Jian Kang, Xiaochi Ma, Yufang Ma
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium tuberculosis
Rv1324
oxidative stress
ferroptosis
pathogenesis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02526-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02526-22

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