Detection of HER2 Amplification in Breast Carcinomas: Comparison of Multiplex Ligation-Dependent Probe Amplification (MLPA) and Fluorescence In Situ Hybridization (FISH) combined with Automated Spot Counting

Detection of HER2 Amplification in Breast Carcinomas: Comparison of Multiplex Ligation-Dependent Probe Amplification (MLPA) and Fluorescence In Situ Hybridization (FISH) combined with Automated Spot Counting

In this study the detection of HER2 gene amplification was evaluated using Fluorescence In Situ Hybridization (FISH; PathVysion) in comparison with Multiplex Ligation-dependent Probe Amplification (MLPA), a PCR based technique. These two methods were evaluated on a series of 46 formalin fixed paraff...

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Bibliographic Details
Main Authors: Elna Moerland, Rens L. H. P. M. van Hezik, Toine C. J. M. van der Aa, Mike W. P. M. van Beek, Adriaan J. C. van den Brule
Format: Article
Language:English
Published: Hindawi Limited 2006-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.1155/2006/741586

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http://dx.doi.org/10.1155/2006/741586

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