Ing4-deficiency promotes a quiescent yet transcriptionally poised state in hematopoietic stem cells

Ing4-deficiency promotes a quiescent yet transcriptionally poised state in hematopoietic stem cells

Summary: Defining the mechanisms that regulate stem cell maintenance, proliferation, and differentiation is critical for identifying therapies for improving stem cell function under stress. Here, we have identified the tumor suppressor, inhibitor of growth 4 (Ing4), as a critical regulator of hemato...

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Bibliographic Details
Main Authors: Zanshé Thompson, Georgina A. Anderson, Marco Hernandez, Carlos Alfaro Quinde, Alissa Marchione, Melanie Rodriguez, Seth Gabriel, Vera Binder, Alison M. Taylor, Katie L. Kathrein
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:iScience
Subjects:
natural sciences
biological sciences
cell biology
stem cell research
specialized functions of cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224017462

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http://www.sciencedirect.com/science/article/pii/S2589004224017462

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